Mesothelioma Definition

Mesothelioma definition :
•    A type of cancer caused by exposure to asbestos.
This cancer is usually considered a tumor of the pleura and not a type of lung cancer.
•    Cancer involving the pleura (the membranes that cover the lungs).
•    A cancer of the lining of the lungs, chest and stomach caused by inhalation of asbestos dust and fibers or asbestos exposure
•    A cancer of cells similar to those forming the lining of the lungs, heart, the abdominal cavity and its organs.
•    A malignant tumor covering the lining of the lung and often associated with asbestos exposure.
•    A tumor or tumors affecting the lining of the chest or abdomen.
•    A malignant tumor of mesothelium caused by the inhalation of asbestos
•    A tumor in the lining of the lungs. Mesothelioma is linked almost exclusively to asbestos exposure.

• Mesothelioma is known as a lethal condition if not detected on time. There is however forms of mesothelioma that cannot be lethal and these ones are known as benign mesothelioma.

Step by step to conduct clinical trials of mesothelioma

Mesothelioma clinical trials are usually conducted in three stages:

• Phase I trials: these trials involved only a few people.

• Phase II trial: The trial involved a larger group of subjects.

• Phase III trial: The trial involved a large number of people from cancer treatment centers simultaneously.

Benefits of mesothelioma clinical trials:
There are many benefits to be gained from clinical trials of mesothelioma.
For Volunteers beneficial for a great social purpose.
Risks involved in participating in mesothelioma clinical trials?
A clinical trial of mesothelioma is only experimental studies of new drugs and new types of treatments.
Is eligibility to participate in clinical trials of mesothelioma?
Usually, no special requirements to participate in clinical trials of mesothelioma.

What type of mesothelioma clinical trials?
There are various types of mesothelioma clinical trials. Among others, such as: Preventive Exams, Exam Screening, Diagnostic Testing, Treatment Trial, Volunteers for this type of experiment is that patients with mesothelioma.
Exam Quality of Life:
Genetics Studies:
that must be done by any volunteers who participate in clinical trials of mesothelioma is everyone who wants to participate in clinical trials must Mesothelioma

Pleural Mesothelioma

Asbestos is a type of naturally occurring mineral that was, for many years mixed with cement, plaster and paint and used in the interiors of houses.
Due to the way that asbestos acts once inside the body it is usually many years later that asbestos related Pleural Mesothelioma is noticed. Pleural Mesothelioma is normally diagnosed when there is a change in the thin layer of membranes that are in the chest. When this pleural lining thickens or starts to calcify it is known as pleural plaques. Pleural Mesothelioma may begin in the pleura but it can soon radiate outwards to the abdomen, the heart and the outer wall of the chest. When this happens and a diagnosis of Pleural Mesothelioma is made the prognosis is not good and many patients with Pleural Mesothelioma are not expected to live much longer than 12 months or so.
When Pleural Mesothelioma is suspected early enough the patient can be treated and this can help them to live much longer than someone who has been diagnosed with full blown Pleural Mesothelioma.
Omen of the symptoms of Pleural Mesothelioma are pain in the lower back, shortness of breath and pain towards the side of the chest. Some people may have problems when swallowing, have a cough that will not go away and in some cases a patient might even be coughing up blood.
. If the disease is caught quickly enough surgery can help to remove the pleura that are affected and the patient will live for longer than someone with advanced Pleural Mesothelioma.

Mesothelioma risk factors

One of the most common risk factor of Mesothelioma is exposure to asbestos. People who work around asbestos and are people who are exposed to thorium dioxide is more susceptible to Mesothelioma. Some experts also pointed out that the x-ray or substances are also responsible for the peritoneal and pleural mesothelioma. And People who are at great risk are those who constantly in touch with Zeolite. Zeolites are minerals that are found in the region Anatoli, Turkey. Some medical experts believe that there is a relationship between simian virus 40 and mesothelioma. However, for this case is still a debate. Tobacco, which said not to be directly responsible for this disease, but the facts prove that the combination of people who consume and those who worked around asbestos 50% more susceptible to Mesothelioma.
Although cancer Mesothelioma is a rare type of cancer, but it does not mean that it's less dangerous. On the contrary, until now there is no proper cure for Mesothelioma and the problems associated with this disease is people can not find it in the early stages. Typically, the majority of people diagnosed with this disease is only able to survive only in a span of 2 years. The only key with which you can fight with the type of the disease to regularly go to the doctor for diagnosis.

Mesothelioma Information

Tumor cells are rarely found mesotelial this very often or most often occurs in the pleura (more rarely in the peritoneum and other places). Mesothelioma is a tumor associated with asbestos exposure in the workplace in 90% of cases; but only 20% of all patients who suffered from pulmonary asbestosis. The risk of life (not influenced by smoking habits) in patients with severe exposure is 7-10% with a latent period between exposure and onset of tumor-25-45 years. Among the asbestos factory workers, carcinoma of the lung tumor is still the most frequently detected or most common, the risk of lung carcinoma experienced a noticeable increase if there is smoking.

Clinical Overview Mesothelioma patients found with complaints of chest pain, dyspnea and recurrent pleural effusions. Mesothelioma is a highly malignant tumor that invades the lungs and can metastasize widely. Some patients with these tumors are still able to survive or just over 2 years.
Morphology Tumor spread diffuse pulmonary fissures on the surface and thus tmembentuk sheath that surrounds the tumor. Epitelioid microscopic patterns of tumor (70%), sarkomatoid (20%) and mixed (biphasic) (10%).
• Pattern epitelioid showed similar cells-epithelium by forming tubular and papillary protrusions that resemble adenocarcinoma. Antigenic characteristics (kalretinin, WT-1 positivity and CK5 / 6) and ultrastructural (microvilli are long and slender) allows these tumors dihedakan with adenocarcinoma (MOC3I positivity and BG8 and have microvilli are short and fat).
• Polo sarkomatoid showed malignant cells resembling fibrosarcoma-shaped coil.