What Symptoms Indicate Metastatic Spread?

Not all mesothelioma symptoms are confined to the site where the cancer originates. The symptoms that are most closely related to local invasion include:

Localized spread to the lymph nodes is most common and occurs in approximately 44% percent of cases.

• Dysphagia (coughing/spitting up blood)
• Horner's syndrome (or other neurological syndromes)
• Laryngeal nerve palsy
• Nerve involvement of the arm

Paraplegia can occur if the cancer spreads to the spinal canal. Metastatic mesothelioma can also obstruct the superior vena cava. Hypoglycemia has also been reported as a clinical feature of invasive mesothelioma, yet this primarily occurs in patients with rare localized fibrous mesothelioma. Clubbing of the fingers and hypertrophic pulmonary osteoarthropathy (HPOA) are even rarer but occur in a handful of malignant mesothelioma cases, primarily when asbestosis is also present.

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